Description
Anonychia congenita is a condition that affects the fingernails and toenails. Individuals with this condition are typically missing all of their fingernails and toenails (anonychia). This absence of nails is noticeable from birth (congenital). In some cases, only part of the nail is missing (hyponychia) or not all fingers and toes are affected. All of the other tissues at the tips of the fingers and toes, including structures that usually support the nail and its growth (such as the nail bed), are normal.
Individuals with anonychia congenita do not have any other health problems related to the condition.
Frequency
Anonychia congenita is a rare condition; its prevalence is unknown.
Causes
Mutations in the RSPO4 gene cause anonychia congenita. The RSPO4 gene provides instructions for making a protein called R-spondin-4. R-spondin-4 plays a role in the Wnt signaling pathway, a series of steps that affect the way cells and tissues develop. Wnt signaling is important for cell division, attachment of cells to one another (adhesion), cell movement (migration), and many other cellular activities. During early development, Wnt signaling plays a critical role in the growth and development of nails. R-spondin-4 is active in the skeleton and contributes to limb formation, particularly at the ends of the fingers and toes where nail development occurs.
RSPO4 gene mutations lead to the production of a protein with little or no function. As a result, R-spondin-4 cannot participate in the Wnt signaling pathway and nails develop improperly or not at all.
Anonychia congenita can also be part of syndromes that affect multiple parts of the body, including Coffin-Siris syndrome and nail-patella syndrome. When anonychia congenita is part of a syndrome, it is caused by mutations in the gene associated with that syndrome.
Learn more about the gene associated with Anonychia congenita
- RSPO4
Inheritance
Anonychia congenita resulting from RSPO4 gene mutations is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.
Other Names for This Condition
- Absent nails
- Anonychia
- Aplastic nails
- Congenital absence of nails
- Hyponychia congenita
Additional Information & Resources
Genetic Testing Information
Patient Support and Advocacy Resources
Catalog of Genes and Diseases from OMIM
Scientific Articles on PubMed
References
- Bergmann C, Senderek J, Anhuf D, Thiel CT, Ekici AB, Poblete-Gutierrez P, vanSteensel M, Seelow D, Nurnberg G, Schild HH, Nurnberg P, Reis A, Frank J, ZerresK. Mutations in the gene encoding the Wnt-signaling component R-spondin 4 (RSPO4)cause autosomal recessive anonychia. Am J Hum Genet. 2006 Dec;79(6):1105-9. doi:10.1086/509789. Epub 2006 Oct 17. Citation on PubMed or Free article on PubMed Central
- Blaydon DC, Ishii Y, O'Toole EA, Unsworth HC, Teh MT, Ruschendorf F, SinclairC, Hopsu-Havu VK, Tidman N, Moss C, Watson R, de Berker D, Wajid M, ChristianoAM, Kelsell DP. The gene encoding R-spondin 4 (RSPO4), a secreted proteinimplicated in Wnt signaling, is mutated in inherited anonychia. Nat Genet. 2006Nov;38(11):1245-7. doi: 10.1038/ng1883. Epub 2006 Oct 15. Citation on PubMed
- Bruchle NO, Frank J, Frank V, Senderek J, Akar A, Koc E, Rigopoulos D, vanSteensel M, Zerres K, Bergmann C. RSPO4 is the major gene in autosomal-recessiveanonychia and mutations cluster in the furin-like cysteine-rich domains of theWnt signaling ligand R-spondin 4. J Invest Dermatol. 2008 Apr;128(4):791-6. doi:10.1038/sj.jid.5701088. Epub 2007 Oct 4. Citation on PubMed
- Khalil S, Hayashi R, Daou L, Staiteieh SA, Abbas O, Bergqvist C, Nemer G,Shimomura Y, Kurban M. A novel mutation in the RSPO4 gene in a patient withautosomal recessive anonychia. Clin Exp Dermatol. 2017 Apr;42(3):313-315. doi:10.1111/ced.13052. Epub 2017 Mar 1. Citation on PubMed
- Khan TN, Klar J, Nawaz S, Jameel M, Tariq M, Malik NA, Baig SM, Dahl N. Novelmissense mutation in the RSPO4 gene in congenital hyponychia and evidence for apolymorphic initiation codon (p.M1I). BMC Med Genet. 2012 Dec 13;13:120. doi:10.1186/1471-2350-13-120. Citation on PubMed or Free article on PubMed Central
- Wasif N, Ahmad W. A novel nonsense mutation in RSPO4 gene underlies autosomalrecessive congenital anonychia in a Pakistani family. Pediatr Dermatol. 2013Jan-Feb;30(1):139-41. doi: 10.1111/j.1525-1470.2011.01587.x. Epub 2012 Feb 3. Citation on PubMed
